{"id":115,"date":"2024-02-01T04:17:31","date_gmt":"2024-02-01T04:17:31","guid":{"rendered":"https:\/\/shennong.jp\/?p=115"},"modified":"2024-11-30T13:40:34","modified_gmt":"2024-11-30T13:40:34","slug":"%e6%85%a3%e8%a1%8c%e8%be%b2%e6%b3%95%e3%81%ae%e7%8f%be%e7%8a%b6","status":"publish","type":"post","link":"https:\/\/shennong.jp\/?p=115","title":{"rendered":"\u6163\u884c\u8fb2\u6cd5\u306e\u73fe\u72b6"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<p>\u304a\u8336\u306f\u5065\u5eb7\u306b\u3044\u3044\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u5f53\u306b\u305d\u3046\u3067\u3057\u3087\u3046\u304b\uff1f\u69d8\u3005\u306a\u73fe\u5834\u3092\u898b\u3066\u304d\u305f\u7d4c\u9a13\u304b\u3089\u3001\u6539\u3081\u3066\u65e5\u672c\u306e\u304a\u8336\u3065\u304f\u308a\u306e\u73fe\u72b6\u3092\u8003\u3048\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u822c\u7684\u306a\u304a\u8336\u4f5c\u308a\u306b\u3001\u6b20\u304b\u305b\u306a\u3044\u306e\u304c\u80a5\u6599\u3068\u8fb2\u85ac\u3067\u3059\u3002\u4eca\u3001\u65e5\u672c\u306e\u304a\u8336\u3065\u304f\u308a\u306e\u73fe\u5834\u3067\u4f7f\u308f\u308c\u3066\u3044\u308b\u8fb2\u85ac\u306f\u300c\u30cd\u30aa\u30cb\u30b3\u30c1\u30ce\u30a4\u30c9\u7cfb\u8fb2\u85ac\u300d\u3067\u3059\u3002\u30cd\u30aa\u30cb\u30b3\u30c1\u30ce\u30a4\u30c9\u7cfb\u8fb2\u85ac\u306f\u52b9\u679c\u304c\u9577\u304f\u6301\u7d9a\u3057\u3001\u8fb2\u85ac\u306e\u6563\u5e03\u56de\u6570\u3092\u6e1b\u3089\u3057\u307e\u3059\u3002\u4e00\u898b\u3001\u8fb2\u4f5c\u696d\u306e\u52b9\u7387\u5316\u304c\u56f3\u3089\u308c\u3066\u3044\u3044\u3088\u3046\u306b\u3082\u601d\u308f\u308c\u307e\u3059\u304c\u3001\u5b9f\u306f\u305d\u306e\u5206\u3001\u8fb2\u85ac\u306e\u542b\u6709\u6fc3\u5ea6\u306f\u4e0a\u304c\u308b\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u3002<br>\u65e5\u672c\u306e\u304a\u8336\u306b\u591a\u304f\u542b\u307e\u308c\u308b\u30cd\u30aa\u30cb\u30b3\u30c1\u30ce\u30a4\u30c9\u7cfb\u8fb2\u85ac\u3002\u679c\u305f\u3057\u3066\u3069\u306e\u3088\u3046\u306a\u8fb2\u85ac\u306a\u306e\u3067\u3057\u3087\u3046\uff1f\u3053\u306e\u8fb2\u85ac\u306b\u3064\u3044\u3066\u8abf\u3079\u3066\u307f\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u3000\u30cd\u30aa\u30cb\u30b3\u30c1\u30ce\u30a4\u30c9\u7cfb\u8fb2\u85ac\u306f\u3001\u5bb3\u866b\u306b\u306f\u6bd2\u6027\u304c\u9ad8\u3044\u304c\u30d2\u30c8\u306b\u306f\u5b89\u5168\u3067\u3042\u308b\u3068\u3055\u308c\u3001\u4e16\u754c\u4e2d\u3067\u4f7f\u7528\u91cf\u304c\u6025\u5897\u3057\u3066\u3044\u308b\u3002\u30cd\u30aa\u30cb\u30b3\u30c1\u30ce\u30a4\u30c9\u306f\u30cb\u30b3\u30c1\u30f3\u985e\u4f3c\u69cb\u9020\u3092\u6301\u3061\u3001\u6606\u866b\u3067\u306f\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\uff08ACh\uff09\u306e\u53d7\u5bb9\u4f53\u3067\u3042\u308b\u30cb\u30b3\u30c1\u30f3\u6027 ACh \u53d7\u5bb9\u4f53\uff08nAChR\uff09\u306b\u5f37\u3044\u30a2\u30b4\u30cb\u30b9\u30c8\u4f5c\u7528\u3092\u3082\u3064\u304c\u3001\u54fa\u4e73\u985e\u3078\u306e\u5f71\u97ff\u306f\u5341\u5206\u8abf\u3079\u3089\u308c\u3066\u3044\u306a\u3044\u3002\u54fa\u4e73\u985e\u306e nAChR \u306f\u81ea\u5f8b\u795e\u7d4c\u3001\u672b\u68a2\u795e\u7d4c\u3067\u4e3b\u8981\u306a\u3060\u3051\u3067\u306a\u304f\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3084\u514d\u75ab\u7cfb\u3067\u3082\u591a\u69d8\u306a\u4f5c\u7528\u3092\u6301\u3061\u3001\u7279\u306b\u767a\u9054\u671f\u306e\u8133\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u50cd\u304d\u304c\u5206\u304b\u3063\u3066\u304d\u305f\u3002\u6700\u8fd1\u30cd\u30aa\u30cb\u30b3\u30c1\u30ce\u30a4\u30c9\u304c\u54fa\u4e73\u985e\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3059\u7814\u7a76\u5831\u544a\u304c\u51fa\u3066\u304d\u3066\u3044\u308b\u3002\u6211\u3005\u306f\u3001\u30cd\u30aa\u30cb\u30b3\u30c1\u30ce\u30a4\u30c9\u304c\u3001\u767a\u9054\u671f\u306e\u30e9\u30c3\u30c8\u57f9\u990a\u795e\u7d4c\u7d30\u80de\u306b nAChR \u3092\u4ecb\u3057\u3066\u3001\u30cb\u30b3\u30c1\u30f3\u540c\u69d8\u306b\uff11\u03bcM \u306e\u4f4e\u6fc3\u5ea6\u304b\u3089\u8208\u596e\u6027\u53cd\u5fdc\u3092\u8d77\u3053\u3059\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u30cb\u30b3\u30c1\u30f3\u306f\u30d2\u30c8\u3078\u306e\u6bd2\u6027\u3001\u7279\u306b\u5b50\u3069\u3082\u306e\u767a\u9054\u3078\u306e\u60aa\u5f71\u97ff\u304c\u5206\u304b\u3063\u3066\u304d\u3066\u304a\u308a\u3001\u30cd\u30aa\u30cb\u30b3\u30c1\u30ce\u30a4\u30c9\u306b\u3088\u308b\u5b50\u3069\u3082\u306e\u8133\u306e\u767a\u9054\u3078\u306e\u5f71\u97ff\u304c\u61f8\u5ff5\u3055\u308c\u308b\u3002<br>\u2014\u5f15\u7528\uff1a\u7b2c20\u56de\u65e5\u672c\u81e8\u5e8a\u74b0\u5883\u533b\u5b66\u4f1a\u5b66\u8853\u96c6\u4f1a\u7279\u96c6<a href=\"https:\/\/www.asahikawa-med.ac.jp\/dept\/mc\/healthy\/jsce\/jjce21_1_46.pdf\">\u300e\u65b0\u8fb2\u85ac\u30cd\u30aa\u30cb\u30b3\u30c1\u30ce\u30a4\u30c9\u7cfb\u8fb2\u85ac\u306e\u30d2\u30c8\u30fb\u54fa\u4e73\u985e\u3078\u306e\u5f71\u97ff\u300f<\/a>2012.<\/p>\n<\/blockquote>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u60a3\u8005\u306e\u751f\u6d3b\u7fd2\u6163\u3068\u3057\u3066\u5171\u901a\u3059\u308b\u7279\u5fb4\u306b\u3001\u5065\u5eb7\u7dad\u6301\u306b\u71b1\u5fc3\u3067\u56fd\u7523\u679c\u7269\u3084\u304a\u8336\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u3052\u3089\u308c\u307e\u3059\u3002\u5b9f\u306f\u3001\u30cd\u30aa\u30cb\u30b3\u30c1\u30ce\u30a4\u30c9\u7cfb\u8fb2\u85ac\u306e\u6b8b\u7559\u57fa\u6e96\u306f\u3001\u6b27\u7c73\u3088\u308a\u3082\u304b\u306a\u308a\u7de9\u3044\u57fa\u6e96\u5024\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u304a\u8336\u3067\u306f\uff25\uff35\u30670.1ppm\u306a\u306e\u306b\u5bfe\u3057\u3066\u3001\u65e5\u672c\u3067\u306f\u305d\u306e500\u500d\u306e50ppm\u306e\u57fa\u6e96\u5024\u3067\u3059\u3002\u5b9f\u969b\u306b\u3001\u9752\u5c71\u6c0f\u3089\u306e\u8abf\u67fb\u3067\u306f\u3001\u308a\u3093\u3054\u3067\u306f4.9ppm\u3001\u8336\u8449\u3067\u306f10\uff5e20ppm\u3001\u8336\u98f2\u6599\u3067\u306f2.5ppm\u306e\u30cd\u30aa\u30cb\u30b3\u30c1\u30ce\u30a4\u30c9\u7cfb\u8fb2\u85ac\u304c\u691c\u51fa\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5065\u5eb7\u306b\u3044\u3044\u3068\u601d\u3063\u3066\u98df\u3079\u3066\u3044\u305f\u3082\u306e\u304c\u5b9f\u306f\u5065\u5eb7\u88ab\u5bb3\u306e\u4e3b\u56e0\u306b\u306a\u3063\u3066\u3044\u305f\u306e\u3067\u3059\u3002<br>\u2014\u5f15\u7528\uff1a<a href=\"https:\/\/kokumin-kaigi.org\/wp-content\/uploads\/2022\/06\/Letter59-2-4.pdf\">\u300e\u4eba\u4f53\u88ab\u5bb3\u306e\u5b9f\u614b\uff5e\u9752\u5c71\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662\u304b\u3089\u306e\u5831\u544a\uff5e\u300f<\/a>\u9752\u5c71\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662\u3000\u533b\u5e2b \u9752\u5c71\u3000\u7f8e\u5b50<\/p>\n<\/blockquote>\n\n\n\n<p>\u65e5\u672c\u306e\u304a\u8336\u3065\u304f\u308a\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u30cd\u30aa\u30cb\u30b3\u30c1\u30ce\u30a4\u30c9\u7cfb\u8fb2\u85ac\u3002\u5c11\u3057\u8abf\u3079\u308b\u3060\u3051\u3067\u3082\u3053\u306e\u3088\u3046\u306a\u8ad6\u6587\u3084\u898b\u89e3\u304c\u51fa\u3066\u304d\u307e\u3057\u305f\u3002<br>\u305d\u308c\u3067\u3082\u56fd\u304c\u8a8d\u3081\u3066\u3044\u308b\u8fb2\u85ac\u3067\u3059\u3002\u5b9f\u969b\u306b\u88ab\u5bb3\u306f\u51fa\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n\n\n\n<p>\u8fb2\u6797\u6c34\u7523\u7701\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u306b\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u30c7\u30fc\u30bf\u304c\u63b2\u8f09\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u8fb2\u85ac\u306e\u4f7f\u7528\u306b\u4f34\u3046\u4e8b\u6545\u53ca\u3073\u88ab\u5bb3\u306e\u767a\u751f\u72b6\u6cc1\u306b\u3064\u3044\u3066\u3001\u904e\u53bb5\u30f6\u5e74\u306e\u4e8b\u6545\u53ca\u3073\u88ab\u5bb3\u306e\u767a\u751f\u72b6\u6cc1\u3092\u307e\u3068\u3081\u305f\u3082\u306e\u3067\u3059\u3002\u8fb2\u5bb6\u3055\u3093\u306e\u5168\u4f53\u6570\u304b\u3089\u6bd4\u3079\u305f\u3089\u6570\u306f\u5c11\u306a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u4eca\u3082\u8fb2\u85ac\u306b\u3088\u308b\u6b7b\u4ea1\u4e8b\u6545\u3084\u4e2d\u6bd2\u306f\u767a\u751f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"693\" src=\"https:\/\/shennong.jp\/wp-content\/uploads\/2024\/11\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-11-30-151122-1024x693.png\" alt=\"\" class=\"wp-image-163\" srcset=\"https:\/\/shennong.jp\/wp-content\/uploads\/2024\/11\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-11-30-151122-1024x693.png 1024w, https:\/\/shennong.jp\/wp-content\/uploads\/2024\/11\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-11-30-151122-300x203.png 300w, https:\/\/shennong.jp\/wp-content\/uploads\/2024\/11\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-11-30-151122-768x519.png 768w, https:\/\/shennong.jp\/wp-content\/uploads\/2024\/11\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-11-30-151122-1536x1039.png 1536w, https:\/\/shennong.jp\/wp-content\/uploads\/2024\/11\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-11-30-151122.png 2008w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">\u56f3\u8868\uff1a\u8fb2\u6797\u6c34\u7523\u7701.<a href=\"https:\/\/www.maff.go.jp\/j\/nouyaku\/n_tekisei\/accident.html\">\u300e\u904e\u53bb5\u30f6\u5e74\u306e\u4e8b\u6545\u53ca\u3073\u88ab\u5bb3\u306e\u767a\u751f\u72b6\u6cc1\u300f<\/a>2022.<\/figcaption><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>\u65e5\u672c\u306f\u3001\u8af8\u5916\u56fd\u306b\u6bd4\u3079\u308b\u3068\u98df\u306e\u5b89\u5168\u6027\u304c\u9ad8\u3044\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u8fb2\u85ac\u3092\u4f7f\u3063\u3066\u3044\u3066\u3082\u305d\u306e\u91cf\u304c\u5c11\u306a\u3051\u308c\u3070\u554f\u984c\u306a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u8abf\u3079\u308b\u3068\u3001\u3053\u3093\u306a\u30c7\u30fc\u30bf\u3082\u51fa\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"544\" src=\"https:\/\/shennong.jp\/wp-content\/uploads\/2024\/11\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-11-30-152438-1024x544.png\" alt=\"\" class=\"wp-image-173\" srcset=\"https:\/\/shennong.jp\/wp-content\/uploads\/2024\/11\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-11-30-152438-1024x544.png 1024w, https:\/\/shennong.jp\/wp-content\/uploads\/2024\/11\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-11-30-152438-300x159.png 300w, https:\/\/shennong.jp\/wp-content\/uploads\/2024\/11\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-11-30-152438-768x408.png 768w, https:\/\/shennong.jp\/wp-content\/uploads\/2024\/11\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-11-30-152438-1536x816.png 1536w, https:\/\/shennong.jp\/wp-content\/uploads\/2024\/11\/\u30b9\u30af\u30ea\u30fc\u30f3\u30b7\u30e7\u30c3\u30c8-2024-11-30-152438.png 1682w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" 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